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Article

Exploiting genomics and natural genetic variation to decode macrophage enhancers.

Trends in immunology - 1 Sept 2015

Romanoski Casey E, Link Verena M, Heinz Sven, Glass Christopher K

Abstract excerpt

The mammalian genome contains on the order of a million enhancer-like regions that are required to establish the identities and functions of specific cell types. Here, we review recent studies in immune cells that have provided insight into the mechanisms that selectively activate certain enhancers in response to cell lineage and environmental signals. We describe a working model wherein distinct classes of...

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Share to Cell Lineage
Share to Chromatin Assembly and Disassembly
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26298065
DOI: 10.1016/j.it.2015.07.006
PMCID: PMC4548828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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