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Article

Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease.

Molecular cell - 7 Oct 2021

Troutman Ty D, Kofman Eric, Glass Christopher K

Abstract excerpt

The development and functional potential of metazoan cells is dependent on combinatorial roles of transcriptional enhancers and promoters. Macrophages provide exceptionally powerful model systems for investigation of mechanisms underlying the activation of cell-specific enhancers that drive transitions in cell fate and cell state. Here, we review recent advances that have expanded appreciation of the diversity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34464593
DOI: 10.1016/j.molcel.2021.08.004
PMCID: PMC8500948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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