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Article

Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes.

Nature immunology - 1 Nov 2023

Bennett Hunter, Troutman Ty D, Zhou Enchen, Spann Nathanael J, Link Verena M, Seidman Jason S, Nickl Christian K, Abe Yohei, Sakai Mashito, Pasillas Martina P, Marlman Justin M, Guzman Carlos, Hosseini Mojgan, Schnabl Bernd, Glass Christopher K

Abstract excerpt

Noncoding genetic variation drives phenotypic diversity, but underlying mechanisms and affected cell types are incompletely understood. Here, investigation of effects of natural genetic variation on the epigenomes and transcriptomes of Kupffer cells derived from inbred mouse strains identified strain-specific environmental factors influencing Kupffer cell phenotypes, including leptin signaling in Kupffer cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37735593
DOI: 10.1038/s41590-023-01631-w
PMCID: PMC10602851

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