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Article

Genetic and epigenetic variation in the lineage specification of regulatory T cells.

eLife - 28 Oct 2015

Arvey Aaron, van der Veeken Joris, Plitas George, Rich Stephen S, Concannon Patrick, Rudensky Alexander Y

Abstract excerpt

Regulatory T (Treg) cells, which suppress autoimmunity and other inflammatory states, are characterized by a distinct set of genetic elements controlling their gene expression. However, the extent of genetic and associated epigenetic variation in the Treg cell lineage and its possible relation to disease states in humans remain unknown. We explored evolutionary conservation of regulatory elements and natural...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 26510014
DOI: 10.7554/eLife.07571
PMCID: PMC4623597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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