Article
Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factor.
Nucleic acids research - 1 Jan 2014
Burdach Jon, Funnell Alister P W, Mak Ka Sin, Artuz Crisbel M, Wienert Beeke, Lim Wooi F, Tan Lit Yeen, Pearson Richard C M, Crossley Merlin
Abstract excerpt
Transcription factors (TFs) are often regarded as being composed of a DNA-binding domain (DBD) and a functional domain. The two domains are considered separable and autonomous, with the DBD directing the factor to its target genes and the functional domain imparting transcriptional regulation. We examined an archetypal zinc finger (ZF) TF, Krüppel-like factor 3 with an N-terminal domain that binds the corepressor...
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