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Article

Engineering a protein scaffold from a PHD finger.

Structure (London, England : 1993) - 1 Jul 2003

Kwan Ann H Y, Gell David A, Verger Alexis, Crossley Merlin, Matthews Jacqueline M, Mackay Joel P

Abstract excerpt

The design of proteins with tailored functions remains a relatively elusive goal. Small size, a well-defined structure, and the ability to maintain structural integrity despite multiple mutations are all desirable properties for such designer proteins. Many zinc binding domains fit this description. We determined the structure of a PHD finger from the transcriptional cofactor Mi2beta and investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12842043
DOI: 10.1016/s0969-2126(03)00122-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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