Article

A domain-resolution map of <i>in vivo</i> DNA binding reveals the regulatory consequences of somatic mutations in zinc finger transcription factors

2019-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Multi-zinc finger proteins constitute the largest class of human transcription factors. Their DNA-binding specificity is usually encoded by a subset of their tandem Cys2His2 zinc finger (ZF) domains – the subset that binds to DNA, however, is often unknown. Here, by combining a context-aware machine-learning-based model of DNA recognition with in vivo binding data, we characterize the sequence...

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Literature Corpus work: 33ee353e-4511-5e79-b8cb-65c95689e6c9
DOI: 10.1101/630756

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