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Article

Rational design, selection and specificity of artificial transcription factors (ATFs): the influence of chromatin in target gene regulation.

Combinatorial chemistry & high throughput screening - 1 Feb 2008

Blancafort Pilar, Beltran Adriana S

Abstract excerpt

Artificial Transcription Factors (ATFs) are engineered DNA-binding proteins designed to bind specific sequences of DNA. ATFs made of Zinc Finger (ZF) domains have been developed to regulate specific genes and phenotypes both in cells and whole organisms. Recently, an emerging application of engineered DNA-binding domains include the specific editing of the genome, the ability to specifically cut, recombine,...

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Identifiers

PMID: 18336208
DOI: 10.2174/138620708783744453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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