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Article

Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins.

Molecular and cellular biology - 1 Nov 2006

Quinlan Kate G R, Nardini Marco, Verger Alexis, Francescato Pierangelo, Yaswen Paul, Corda Daniela, Bolognesi Martino, Crossley Merlin

Abstract excerpt

Numerous transcription factors recruit C-terminal binding protein (CtBP) corepressors. We show that the large zinc finger protein ZNF217 contacts CtBP. ZNF217 is encoded by an oncogene frequently amplified in tumors. ZNF217 contains a typical Pro-X-Asp-Leu-Ser (PXDLS) motif that binds in CtBP's PXDLS-binding cleft. However, ZNF217 also contains a second motif, Arg-Arg-Thr (RRT), that binds a separate surface on...

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Identifiers

PMID: 16940172
DOI: 10.1128/MCB.00680-06
PMCID: PMC1636751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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