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Article

Zinc Finger Nucleases as tools to understand and treat human diseases

1 Jul 2010

Abstract excerpt

Recent work has shown that it is possible to target regulatory elements to DNA sequences of an investigator's choosing, increasing the armamentarium for probing gene function. In this review, we discuss the development and use of designer zinc finger proteins (ZFPs) as sequence specific tools. While the main focus of this review is to discuss the attachment of the FokI nuclease to ZFPs and the ability of the...

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PMID: 20594338
DOI: 10.1186/1741-7015-8-42

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