Article

Quantitative analysis of ZFY and CTCF reveals dependent recognition of tandem zinc finger proteins

2019-05-15

Abstract excerpt

The human genome contains around 800 C2H2 Zinc Finger Proteins (ZFPs), and many of them are composed of long tandem arrays of zinc fingers. Current motif prediction models assume longer finger arrays correspond to longer DNA-binding motifs and higher specificity. However, recent experimental efforts to identify ZFP binding sites in vivo contradict this assumption, with many having short motifs. Here, we systemati...

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Literature Corpus work: 28610d97-4e0c-5247-b6a2-c29e1213d135
DOI: 10.1101/637298

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