Shared nucleotide flanks confer transcriptional competency to bZip core motifs.

Abstract excerpt

Sequence-specific DNA binding recruits transcription factors (TFs) to the genome to regulate gene expression. Here, we perform high resolution mapping of CEBP proteins to determine how sequence dictates genomic occupancy. We demonstrate a fundamental difference between the sequence repertoire utilized by CEBPs in vivo versus the palindromic sequence preference reported by classical in vitro models, by identifying...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Basic-Leucine Zipper Transcription Factors
• Share to CCAAT-Enhancer-Binding Proteins