Article
Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.
Environmental and molecular mutagenesis - 1 Dec 2013
Horibata Katsuyoshi, Ukai Akiko, Kimoto Takafumi, Suzuki Tetsuya, Kamoshita Nagisa, Masumura Kenichi, Nohmi Takehiko, Honma Masamitsu
Abstract excerpt
The recently developed Pig-a mutation assay is based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient red blood cells caused by a forward mutation in the Pig-a gene. Because the assay can be conducted in nontransgenic animals and the mutations accumulate with...
Topics
- 4-Nitroquinoline-1-oxide
- Animals
- Benzo(a)pyrene
- Biological Assay
- DNA Damage
- Erythrocytes
- Escherichia coli Proteins
- Ethylnitrosourea
- Flow Cytometry
- Liver
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutagenicity Tests