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Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.

Environmental and molecular mutagenesis - 1 Dec 2013

Horibata Katsuyoshi, Ukai Akiko, Kimoto Takafumi, Suzuki Tetsuya, Kamoshita Nagisa, Masumura Kenichi, Nohmi Takehiko, Honma Masamitsu

Abstract excerpt

The recently developed Pig-a mutation assay is based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient red blood cells caused by a forward mutation in the Pig-a gene. Because the assay can be conducted in nontransgenic animals and the mutations accumulate with repeat dosing, we believe that the Pig-a assay could be integrated into repeat-dose toxicology studies and provides an...

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PMID: 24105957
DOI: 10.1002/em.21818

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GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evaluation of in vivo genotoxicity induced by N-ethyl-N-nitrosourea, benzo[a]pyrene, and 4-nitroquinoline-1-oxide in the Pig-a and gpt assays.PMID 24105957Read ↗

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs.Semantic proximity Read ↗

The PIGRET assay, a method for measuring Pig-a gene mutation in reticulocytes, is reliable as a short-term in vivo genotoxicity test: Summary of the MMS/JEMS-collaborative study across 16 laboratories using 24 chemicals.Semantic proximity Read ↗

Pyrene did not induce gene mutation in red blood cell Pig-a assay and PIGRET assay in rats.Semantic proximity Read ↗

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.Semantic proximity Read ↗

In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation.Semantic proximity Read ↗

Report on stage III Pig-a mutation assays using N-ethyl-N-nitrosourea-comparison with other in vivo genotoxicity endpoints.Semantic proximity Read ↗

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.Semantic proximity Read ↗

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate.Semantic proximity Read ↗

Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.Semantic proximity Read ↗

Report on stage III Pig-a mutation assays using benzo[a]pyrene.Semantic proximity Read ↗

In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

Analysis of mutations in the Pig-a gene of spleen T-cells from N-ethyl-N-nitrosourea-treated fisher 344 rats.Semantic proximity Read ↗

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