Article
Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.
Mutation research. Genetic toxicology and environmental mutagenesis - 1 Apr 2018
Khanal Sumee, Singh Priyanka, Avlasevich Svetlana L, Torous Dorothea K, Bemis Jeffrey C, Dertinger Stephen D
Abstract excerpt
Regulatory guidance documents stress the value of assessing multiple tissues and the most appropriate endpoints when evaluating chemicals for in vivo genotoxic potential. However, conducting several independent studies to consider multiple endpoints and/or tissue compartments is resource intensive. Furthermore, conventional approaches for scoring genotoxicity endpoints are slow, tedious, and less objective than...
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