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Article

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2010

Phonethepswath Souk, Franklin Dean, Torous Dorothea K, Bryce Steven M, Bemis Jeffrey C, Raja Sarojini, Avlasevich Svetlana, Weller Pamela, Hyrien Ollivier, Palis James, Macgregor James T, Dertinger Stephen D

Abstract excerpt

An in vivo mutation assay has been developed based on flow cytometric enumeration of glycosylphosphatidylinositol (GPI) anchor-deficient rat erythrocytes. With this method, blood is incubated with anti-CD59-PE and SYTO 13 dye, and flow cytometry is used to score the frequency of CD59-negative erythrocytes. The experiments described herein were designed to define the kinetics of mutant erythrocyte appearance and...

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PMID: 19965957
DOI: 10.1093/toxsci/kfp289
PMCID: PMC2902916

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GPI

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Source receipt: pubmed, retrieved 7 Sept 2026.

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