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Article

Pyrene did not induce gene mutation in red blood cell Pig-a assay and PIGRET assay in rats.

Mutation research. Genetic toxicology and environmental mutagenesis - 15 Nov 2016

Yoshida Ikuma, Matsumoto Akemi, Sakai Yumi, Harada Yumiko, Hashizume Tsuneo

Abstract excerpt

A new in vivo gene mutation assay has been developed based on the phosphatidylinositol glycan anchor biosynthesis, Class A gene (Pig-a in rodents) as an endogenous reporter. Although a large number of chemicals have been evaluated in the rat Pig-a assay in 28-day repeat dose regimens, there was limited reporting of rat Pig-a assay after a single dose. A collaborative study by the Mammalian Mutagenicity Study...

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Identifiers

PMID: 27931814
DOI: 10.1016/j.mrgentox.2016.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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