Article
A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat.
Biochemical and biophysical research communications - 1 Nov 2013
Yamamoto Takashi, Izumi-Yamamoto Kozue, Iizuka Yoko, Shirota Midori, Nagase Miki, Fujita Toshiro, Gotoda Takanari
Abstract excerpt
Two different strains of the spontaneously hypertensive rat (SHR) exist, either with or without a Cd36 mutation. In the F2 population derived from a cross between these two SHR strains, the mutant Cd36 allele was tightly linked to differences in metabolic phenotypes but not to those in fat pad weight. This suggested the existence of another crucial mutation related to adiposity. Linkage analysis of this F2...
Topics
- 3T3-L1 Cells
- Adipocytes
- Adipogenesis
- Adipose Tissue
- Adiposity
- Animals
- CCAAT-Enhancer-Binding Protein-alpha
- CCAAT-Enhancer-Binding Protein-beta
- Fats
- Gene Knockdown Techniques