Article
Identification of a mutation in ADD1/SREBP-1 in the spontaneously hypertensive rat.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2001
Pravenec M, Jansa P, Kostka V, Zídek V, Kren V, Forejt J, Kurtz T W
Abstract excerpt
It has recently been proposed that primary mutations in genes involved in fatty acid and lipid metabolism may contribute to the pathogenesis of insulin resistance and dyslipidemia often observed in spontaneous forms of hypertension. In the current study in the spontaneously hypertensive rat (SHR), we mapped and sequenced the gene encoding a key transcription factor known as ADD1 (adipocyte determination and...
Topics
- Amino Acid Sequence
- Animals
- Blood Pressure
- CCAAT-Enhancer-Binding Proteins
- Cholesterol
- Chromosome Mapping
- Crosses, Genetic
- DNA-Binding Proteins
- Gene Transfer Techniques
- Genetic Markers
- Genotype
- Heart Rate
- Hypertension