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Article

Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat.

Disease models & mechanisms - 1 Mar 2017

Coan Philip M, Hummel Oliver, Garcia Diaz Ana, Barrier Marjorie, Alfazema Neza, Norsworthy Penny J, Pravenec Michal, Petretto Enrico, Hübner Norbert, Aitman Timothy J

Abstract excerpt

We previously mapped hypertension-related insulin resistance quantitative trait loci (QTLs) to rat chromosomes 4, 12 and 16 using adipocytes from F2 crosses between spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats, and subsequently identified Cd36 as the gene underlying the chromosome 4 locus. The identity of the chromosome 12 and 16 genes remains unknown. To identify whole-body phenotypes associated...

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Identifiers

PMID: 28130354
DOI: 10.1242/dmm.026716
PMCID: PMC5374317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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