Gap junction protein locus on chromosome 18 cosegregates with body weight in the spontaneously hypertensive rat.

doi:10.1291/hypres.18.63

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Article

Gap junction protein locus on chromosome 18 cosegregates with body weight in the spontaneously hypertensive rat.

Hypertension research : official journal of the Japanese Society of Hypertension - 1 Mar 1995

Katsuya T, Takami S, Higaki J, Serikawa T, Mikami H, Miki T, Ogihara T

Abstract excerpt

To detect genetic predisposing factors for hypertension, we screened the genome of the spontaneously hypertensive rat (SHR). We determined the genotypes of all F2 rats at polymorphic sites between the two strains, using the DNA of F2 rats derived from mating of SHR and Wistar-Kyoto rats (WKY). Cosegregation analysis was conducted to assess whether the genotypes of polymorphic markers associate with any phenotypic...

Topics

Analysis of Variance
Animals
Base Sequence
Body Weight
Chromosome Mapping
Connexin 43
Female
Genetic Linkage
Genetic Markers
Genotype
Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Polymerase Chain Reaction

Rats

Rats, Inbred SHR

Rats, Inbred WKY

Source

Open in PubMed

Identifiers

PMID: 7584912
DOI: 10.1291/hypres.18.63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7584912-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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