Article
Identification of mutated Srebf1 as a QTL influencing risk for hepatic steatosis in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2008
Pravenec Michal, Kazdova Ludmila, Landa Vladimir, Zidek Vaclav, Mlejnek Petr, Simakova Miroslava, Jansa Petr, Forejt Jiri, Kren Vladimir, Krenova Drahomira, Qi Nathan, Wang Jia-Ming, Chan Derrick, Aitman Timothy J, Kurtz Theodore W
Abstract excerpt
Approximately 30% of patients with hypertension have hepatic steatosis, and it has recently been proposed that fatty liver be considered a feature of the metabolic syndrome. Obesity, diet, and level of physical activity are likely factors modulating risk for hepatic steatosis, however genetic factors could also influence susceptibility or resistance to fatty liver in hypertensive or normotensive subjects. In...
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