Article
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.
Nature genetics - 1 Jan 1999
Aitman T J, Glazier A M, Wallace C A, Cooper L D, Norsworthy P J, Wahid F N, Al-Majali K M, Trembling P M, Mann C J, Shoulders C C, Graf D, St Lezin E, Kurtz T W, Kren V, Pravenec M, Ibrahimi A, Abumrad N A, Stanton L W, Scott J
Abstract excerpt
The human insulin-resistance syndromes, type 2 diabetes, obesity, combined hyperlipidaemia and essential hypertension, are complex disorders whose genetic basis is unknown. The spontaneously hypertensive rat (SHR) is insulin resistant and a model of these human syndromes. Quantitative trait loci...
Topics
- Animals
- Base Sequence
- CD36 Antigens
- Cell Membrane
- Chromosome Mapping
- DNA, Complementary
- Fatty Acids
- Fatty Acids, Nonesterified
- Female
- Gene Deletion
- Gene Duplication
- Gene Expression
- Genetic Linkage