Article
Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes.
Diabetes care - 1 Feb 2014
Giannini Cosimo, Dalla Man Chiara, Groop Leif, Cobelli Claudio, Zhao Hongyu, Shaw Melissa M, Duran Elvira, Pierpont Bridget, Bale Allen E, Caprio Sonia, Santoro Nicola
Abstract excerpt
OBJECTIVE: Paralleling the rise of pediatric obesity, the prevalence of impaired glucose tolerance (IGT) and type 2 diabetes (T2D) is increasing among youth. In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in...