Article
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing β-Cell Function and Hepatic Insulin Sensitivity.
Diabetes care - 1 Aug 2017
Cropano Catrina, Santoro Nicola, Groop Leif, Dalla Man Chiara, Cobelli Claudio, Galderisi Alfonso, Kursawe Romy, Pierpont Bridget, Goffredo Martina, Caprio Sonia
Abstract excerpt
OBJECTIVE: In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) in obese adolescents. RESEARCH DESIGN AND METHODS: The rs7903146 variant in the TCF7L2 gene was genotyped in a multiethnic cohort of 955 youths. All subjects underwent an oral glucose tolerance test with the use of the Oral Minimal...
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