Article
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants.
Diabetes - 1 Aug 2017
Wood Andrew R, Jonsson Anna, Jackson Anne U, Wang Nan, van Leewen Nienke, Palmer Nicholette D, Kobes Sayuko, Deelen Joris, Boquete-Vilarino Lorena, Paananen Jussi, Stančáková Alena, Boomsma Dorret I, de Geus Eco J C, Eekhoff Elisabeth M W, Fritsche Andreas, Kramer Mark, Nijpels Giel, Simonis-Bik Annemarie, van Haeften Timon W, Mahajan Anubha, Boehnke Michael, Bergman Richard N, Tuomilehto Jaakko, Collins Francis S, Mohlke Karen L, Banasik Karina, Groves Christopher J, McCarthy Mark I, Pearson Ewan R, Natali Andrea, Mari Andrea, Buchanan Thomas A, Taylor Kent D, Xiang Anny H, Gjesing Anette P, Grarup Niels, Eiberg Hans, Pedersen Oluf, Chen Yii-Derr, Laakso Markku, Norris Jill M, Smith Ulf, Wagenknecht Lynne E, Baier Leslie, Bowden Donald W, Hansen Torben, Walker Mark, Watanabe Richard M, 't Hart Leen M, Hanson Robert L, Frayling Timothy M
Abstract excerpt
Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first-phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 individuals without diabetes from 10 studies. We aimed to refine the...
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