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Article

Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis.

The Journal of clinical endocrinology and metabolism - 1 Jun 2013

Prudente Sabrina, Morini Eleonora, Marselli Lorella, Baratta Roberto, Copetti Massimiliano, Mendonca Christine, Andreozzi Francesco, Chandalia Manisha, Pellegrini Fabio, Bailetti Diego, Alberico Federica, Shah Hetal, Abate Nicola, Sesti Giorgio, Frittitta Lucia, Marchetti Piero, Doria Alessandro, Trischitta Vincenzo

Abstract excerpt

CONTEXT: Reduced insulin signaling in insulin secreting β-cells causes defective insulin secretion and hyperglycemia in mice. OBJECTIVE: We investigated whether functional polymorphisms affecting insulin signaling (ie, ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; and TRIB3 Q84R, rs2295490) exert a joint effect on insulin secretion and abnormal glucose homeostasis (AGH). DESIGN: Insulin secretion was evaluated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cell Cycle Proteins

Insulin Receptor Substrate Proteins

Insulin Secretion

Phosphoric Diester Hydrolases

Pyrophosphatases

Source

Open in PubMed Open full text

Identifiers

PMID: 23633196
DOI: 10.1210/jc.2012-4282
PMCID: PMC6618023

Genes

ENPP1
IRS1
TRIB3

Variants

rs1044498
rs1044498
rs1044498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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