Article
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.
Diabetes - 1 Jun 2014
Dimas Antigone S, Lagou Vasiliki, Barker Adam, Knowles Joshua W, Mägi Reedik, Hivert Marie-France, Benazzo Andrea, Rybin Denis, Jackson Anne U, Stringham Heather M, Song Ci, Fischer-Rosinsky Antje, Boesgaard Trine Welløv, Grarup Niels, Abbasi Fahim A, Assimes Themistocles L, Hao Ke, Yang Xia, Lecoeur Cécile, Barroso Inês, Bonnycastle Lori L, Böttcher Yvonne, Bumpstead Suzannah, Chines Peter S, Erdos Michael R, Graessler Jurgen, Kovacs Peter, Morken Mario A, Narisu Narisu, Payne Felicity, Stancakova Alena, Swift Amy J, Tönjes Anke, Bornstein Stefan R, Cauchi Stéphane, Froguel Philippe, Meyre David, Schwarz Peter E H, Häring Hans-Ulrich, Smith Ulf, Boehnke Michael, Bergman Richard N, Collins Francis S, Mohlke Karen L, Tuomilehto Jaakko, Quertemous Thomas, Lind Lars, Hansen Torben, Pedersen Oluf, Walker Mark, Pfeiffer Andreas F H, Spranger Joachim, Stumvoll Michael, Meigs James B, Wareham Nicholas J, Kuusisto Johanna, Laakso Markku, Langenberg Claudia, Dupuis Josée, Watanabe Richard M, Florez Jose C, Ingelsson Erik, McCarthy Mark I, Prokopenko Inga
Abstract excerpt
Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processing, insulin secretion, and insulin sensitivity. We included data from up to 58,614 nondiabetic subjects with basal...
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