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Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.

Human molecular genetics - 3 Mar 2022

Balkhiyarova Zhanna, Luciano Rosa, Kaakinen Marika, Ulrich Anna, Shmeliov Aleksey, Bianchi Marzia, Chioma Laura, Dallapiccola Bruno, Prokopenko Inga, Manco Melania

Abstract excerpt

Epidemic obesity is the most important risk factor for prediabetes and type 2 diabetes (T2D) in youth as it is in adults. Obesity shares pathophysiological mechanisms with T2D and is likely to share part of the genetic background. We aimed to test if weighted genetic risk scores (GRSs) for T2D, fasting glucose (FG) and fasting insulin (FI) predict glycaemic traits and if there is a causal relationship between...

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Identifiers

PMID: 34590674
DOI: 10.1093/hmg/ddab287
PMCID: PMC8895752

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