Allele summation of diabetes risk genes predicts impaired glucose tolerance in female and obese individuals.

Abstract excerpt

INTRODUCTION: Single nucleotide polymorphisms (SNPs) in approximately 40 genes have been associated with an increased risk for type 2 diabetes (T2D) in genome-wide association studies. It is not known whether a similar genetic impact on the risk of prediabetes (impaired glucose tolerance [IGT] or impaired fasting glycemia [IFG]) exists. METHODS: In our cohort of 1442 non-diabetic subjects of European origin...

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• Alleles
• Cohort Studies
• Diabetes Complications
• Genetic Predisposition to Disease
• Glucose Tolerance Test