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Article

Deciphering gene expression program of MAP3K1 in mouse eyelid morphogenesis.

Developmental biology - 1 Feb 2013

Jin Chang, Chen Jing, Meng Qinghang, Carreira Vinicius, Tam Neville N C, Geh Esmond, Karyala Saikumar, Ho Shuk-Mei, Zhou Xiangtian, Medvedovic Mario, Xia Ying

Abstract excerpt

Embryonic eyelid closure involves forward movement and ultimate fusion of the upper and lower eyelids, an essential step of mammalian ocular surface development. Although its underlying mechanism of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is required for eyelid closure. Here we investigate the molecular signatures of MAP3K1 in eyelid morphogenesis. At...

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Identifiers

PMID: 23201579
DOI: 10.1016/j.ydbio.2012.11.020
PMCID: PMC3549005

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