Article
Epithelial SOX11 regulates eyelid closure during embryonic eye development.
Biochemical and biophysical research communications - 16 Apr 2021
Nunomura Satoshi, Nanri Yasuhiro, Lefebvre Véronique, Izuhara Kenji
Abstract excerpt
Fibroblast growth factor (FGF10)-mediated signals are essential for embryonic eyelid closure in mammals. Systemic SOX11-deficient mice are born with unclosed eyelids, suggesting a possible role of SOX11 in eyelid closure. However, the underlying mechanisms of this process remain unclear. In this study, we show that epithelial deficiency of SOX11 causes a defect in the extension of the leading edge of the eyelid,...
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