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Article

Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.

Developmental biology - 1 Nov 2014

Meng Qinghang, Mongan Maureen, Wang Jingjing, Tang Xiaofang, Zhang Jinling, Kao Winston, Xia Ying

Abstract excerpt

Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and promotes the eyelid inferior epithelial cell elongation and epithelium protrusion. Following...

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Identifiers

PMID: 25224220
DOI: 10.1016/j.ydbio.2014.09.001
PMCID: PMC4204485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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