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Article

GPR48 regulates epithelial cell proliferation and migration by activating EGFR during eyelid development.

Investigative ophthalmology & visual science - 1 Oct 2008

Jin Chang, Yin Furong, Lin Mimi, Li Hongxia, Wang Zhenlian, Weng Jinsheng, Liu Mingyao, Da Dong Xiang, Qu Jia, Tu LiLi

Abstract excerpt

PURPOSE: Eyelid development is a dynamic process involving cell proliferation, differentiation, and migration regulated by a number of growth factors and cytokines. Mice deficient in the orphan G protein-coupled receptor 48 (GPR48) showed an eye open at birth (EOB) phenotype. In this study, the authors attempted to clarify the role of GPR48 in eyelid development and the molecular mechanisms leading to the EOB...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18487371
DOI: 10.1167/iovs.08-1860

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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