Article
Eyelid closure in embryogenesis is required for ocular adnexa development.
Investigative ophthalmology & visual science - 6 Nov 2014
Meng Qinghang, Mongan Maureen, Carreira Vinicius, Kurita Hisaka, Liu Chia-Yang, Kao Winston W-Y, Xia Ying
Abstract excerpt
PURPOSE: Mammalian eye development requires temporary fusion of the upper and lower eyelids in embryogenesis. Failure of lid closure in mice leads to an eye open at birth (EOB) phenotype. Many genetic mutant strains develop this phenotype and studies of the mutants lead to a better understanding of the signaling mechanisms of morphogenesis. The present study investigates the roles of lid closure in eye...
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