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Article

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.

Cell reports - 5 Nov 2019

Jin Steven W, Alsahafi Nirmin, Kuang Xiaomei T, Swann Shayda A, Toyoda Mako, Göttlinger Heinrich, Walker Bruce D, Ueno Takamasa, Finzi Andrés, Brumme Zabrina L, Brockman Mark A

Abstract excerpt

HIV-1 Nef enhances virion infectivity by counteracting host restriction factor SERINC5; however, the impact of natural Nef polymorphisms on this function is largely unknown. We characterize SERINC5 downregulation activity of 91 primary HIV-1 subtype B nef alleles, including isolates from 45 elite controllers and 46 chronic progressors. Controller-derived Nef clones display lower ability to downregulate SERINC5...

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Source

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Identifiers

PMID: 31693887
DOI: 10.1016/j.celrep.2019.10.007
PMCID: PMC6925589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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