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Article

Attenuation of multiple Nef functions in HIV-1 elite controllers

7 Jan 2013

Abstract excerpt

BACKGROUND: Impaired HIV-1 Gag, Pol, and Env function has been described in elite controllers (EC) who spontaneously suppress plasma viremia to < 50 RNA copies/mL; however, activity of the accessory protein Nef remains incompletely characterized. We examined the ability of 91 Nef clones, isolated from plasma of 45 EC and 46 chronic progressors (CP), to down-regulate HLA class I and CD4, up-regulate HLA class II...

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PMID: 23289738
DOI: 10.1186/1742-4690-10-1

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