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Article

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.

The Journal of biological chemistry - 12 Sept 2014

Ng Chai Ann, Phan Kevin, Hill Adam P, Vandenberg Jamie I, Perry Matthew D

Abstract excerpt

The intracellular domains of many ion channels are important for fine-tuning their gating kinetics. In Kv11.1 channels, the slow kinetics of channel deactivation, which are critical for their function in the heart, are largely regulated by the N-terminal N-Cap and Per-Arnt-Sim (PAS) domains, as well as the C-terminal cyclic nucleotide-binding homology (cNBH) domain. Here, we use mutant cycle analysis to probe for...

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Identifiers

PMID: 25074935
DOI: 10.1074/jbc.M114.558379
PMCID: PMC4162183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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