Article

A different mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

2021-09-22

Abstract excerpt

<h4>ABSTRACT</h4> A large class of K + channels display a time-dependent phenomenon called C-type inactivation whereby prolonged activation by an external stimulus leads to a non-conductive conformation of the selectivity filter. C-type inactivation is of great physiological importance particularly in voltage-activated K + channels (Kv), affecting the firing patterns of neurons and shaping cardiac action potent...

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Literature Corpus work: d0f2f274-55be-5e96-b2c9-e37a6e486771
DOI: 10.1101/2021.09.22.461404

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