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Article

Amino-terminal determinants of U-type inactivation of voltage-gated K+ channels.

The Journal of biological chemistry - 9 Aug 2002

Kurata Harley T, Soon Gordon S, Eldstrom Jodene R, Lu Grace W K, Steele David F, Fedida David

Abstract excerpt

The T1 domain is a cytosolic NH2-terminal domain present in all Kv (voltage-dependent potassium) channels, and is highly conserved between Kv channel subfamilies. Our characterization of a truncated form of Kv1.5 (Kv1.5deltaN209) expressed in myocardium demonstrated that deletion of the NH2 terminus of Kv1.5 imparts a U-shaped inactivation-voltage relationship to the channel, and prompted us to investigate the...

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Identifiers

PMID: 12021261
DOI: 10.1074/jbc.M111470200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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