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Article

Inactivation of the Kv2.1 channel through electromechanical coupling.

Nature - 1 Oct 2023

Fernández-Mariño Ana I, Tan Xiao-Feng, Bae Chanhyung, Huffer Kate, Jiang Jiansen, Swartz Kenton J

Abstract excerpt

The Kv2.1 voltage-activated potassium (Kv) channel is a prominent delayed-rectifier Kv channel in the mammalian central nervous system, where its mechanisms of activation and inactivation are critical for regulating intrinsic neuronal excitability1,2. Here we present structures of the Kv2.1 channel in a lipid environment using cryo-electron microscopy to provide a framework for exploring its functional mechanisms...

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Identifiers

PMID: 37758949
DOI: 10.1038/s41586-023-06582-8
PMCID: PMC10567553

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