Article
Molecular determinants of U-type inactivation in Kv2.1 channels.
Biophysical journal - 3 Aug 2011
Cheng Y M, Azer J, Niven C M, Mafi P, Allard C R, Qi J, Thouta S, Claydon T W
Abstract excerpt
Kv2.1 channels exhibit a U-shaped voltage-dependence of inactivation that is thought to represent preferential inactivation from preopen closed states. However, the molecular mechanisms underlying so-called U-type inactivation are unknown. We have performed a cysteine scan of the S3-S4 and S5-P-loop linkers and found sites that are important for U-type inactivation. In the S5-P-loop linker, U-type inactivation...
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