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Article

The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.

Biophysical journal - 7 Nov 2017

Dou Ying, Macdonald Logan C, Wu Yue, Fedida David

Abstract excerpt

Kv11.1 (hERG) is a voltage-gated potassium channel that shows very slow ionic current activation kinetics, and an unusual underlying biphasic gating charge movement with fast and slow components that differ greatly in time course. The structural basis and role of the fast component of gating charge (Qfast) is unclear, and its relationship to the slow activation of hERG channels is not understood. In this study we...

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Identifiers

PMID: 29117522
DOI: 10.1016/j.bpj.2017.09.004
PMCID: PMC5685676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.PMID 29117522Read ↗

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