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Article

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2008

Piper David R, Rupp Jason, Sachse Frank B, Sanguinetti Michael C, Tristani-Firouzi Martin

Abstract excerpt

HERG1 K(+) channels are critical for modulating the duration of the cardiac action potential. The role of hERG1 channels in maintaining electrical stability in the heart derives from their unusual gating properties: slow activation and fast inactivation. HERG1 channel inactivation is intrinsically voltage sensitive and is not coupled to activation in the same way as in the Shaker family of K(+) channels. We...

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Source

Identifiers

PMID: 18209470
DOI: 10.1159/000113745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels.PMID 18209470Read ↗

Voltage sensor movement in the hERG K+ channel.Semantic proximity Read ↗

Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels.Semantic proximity Read ↗

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.Semantic proximity Read ↗

The pore domain outer helix contributes to both activation and inactivation of the HERG K+ channel.Semantic proximity Read ↗

S4 mutations alter the single-channel gating kinetics of Shaker K+ channels.Semantic proximity Read ↗

Fast and slow voltage sensor movements in HERG potassium channels.Semantic proximity Read ↗

The neutral, hydrophobic isoleucine at position I521 in the extracellular S4 domain of hERG contributes to channel gating equilibrium.Semantic proximity Read ↗

The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.Semantic proximity Read ↗

Molecular bases for the asynchronous activation of sodium and potassium channels required for nerve impulse generation.Semantic proximity Read ↗

A highly conserved alanine in the S6 domain of the hERG1 K+ channel is required for normal gating.Semantic proximity Read ↗

Mutations in the S6 gate isolate a late step in the activation pathway and reduce 4-AP sensitivity in shaker K(v) channel.Semantic proximity Read ↗

Non-native R1 substitution in the s4 domain uniquely alters Kv4.3 channel gating.Semantic proximity Read ↗

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