Article
A low-frequency GLIS3 variant associated with resistance to Japanese type 1 diabetes.
Biochemical and biophysical research communications - 9 Aug 2013
Awata Takuya, Yamashita Hisakuni, Kurihara Susumu, Morita-Ohkubo Tomoko, Miyashita Yumi, Katayama Shigehiro, Kawasaki Eiji, Tanaka Shoichiro, Ikegami Hiroshi, Maruyama Taro, Shimada Akira, Takahashi Kazuma, Kawabata Yumiko, Kobayashi Tetsuro, Nishida Nao, Mawatari Yoriko
Abstract excerpt
The role of low-frequency variants in type 1 diabetes (T1D) susceptibility still remains to be clarified. In the present study, we analyzed low-frequency variants of the T1D candidate genes in Japanese. We first screened for protein-changing variants of 24 T1D candidate genes in 96 T1D patients and 96 control subjects, and then the association with T1D was tested in 706 T1D patients and 863 control subjects...
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