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Article

A murine model of neonatal diabetes mellitus in Glis3-deficient mice.

FEBS letters - 18 Jun 2009

Watanabe Naoki, Hiramatsu Kentaro, Miyamoto Rieko, Yasuda Kaoru, Suzuki Norihiko, Oshima Naoko, Kiyonari Hiroshi, Shiba Dai, Nishio Saori, Mochizuki Toshio, Yokoyama Takahiko, Maruyama Shoichi, Matsuo Seiichi, Wakamatsu Yuko, Hashimoto Hisashi

Abstract excerpt

Glis3 is a member of the Gli-similar subfamily. GLIS3 mutations in humans lead to neonatal diabetes, hypothyroidism, and cystic kidney disease. We generated Glis3-deficient mice by gene-targeting. The Glis3(-/-) mice had significant increases in the basal blood sugar level during the first few days after birth. The high levels of blood sugar are attributed to a decrease in the Insulin mRNA level in the pancreas...

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Source

Identifiers

PMID: 19481545
DOI: 10.1016/j.febslet.2009.05.039

Genes

GLIS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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