Article
Variants of neurogenin 3 gene are not associated with Type II diabetes in Japanese subjects.
Diabetologia - 1 Feb 2001
Okada T, Tobe K, Hara K, Yasuda K, Kawaguchi Y, Ikegami H, Ito C, Kadowaki T
Abstract excerpt
AIMS/HYPOTHESIS: Neurogenin 3 (ngn3) is a transcription factor expressed in the endocrine precursor cells of the pancreas. It has recently been reported that ngn3-deficient mice show absence of pancreatic endocrine cells and die of postnatal diabetes. The purpose of this investigation was to screen for polymorphisms of the ngn3 gene and to test whether these polymorphisms are associated with Type II...
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