Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM.

doi:10.2337/diacare.21.5.753

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Article

Codon 972 polymorphism of the insulin receptor substrate-1 gene in impaired glucose tolerance and late-onset NIDDM.

Diabetes care - 1 May 1998

Yamada K, Yuan X, Ishiyama S, Shoji S, Kohno S, Koyama K, Koyanagi A, Koyama W, Nonaka K

Abstract excerpt

OBJECTIVE: To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM. RESEARCH DESIGN AND METHODS: The genotype of 1,106 Japanese subjects consisting of 310 subjects with NIDDM, 305 subjects with IGT, and 491 normal control subjects was analyzed by an allele-specific assay using polymerase chain reaction and restriction...

Topics

Adult
Age Factors
Age of Onset
Aged
Alleles
Amino Acid Substitution
Blood Glucose
Codon
Diabetes Mellitus, Type 2
Family Health
Fasting
Female
Gene Frequency
Genes

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Glucose Intolerance

Glucose Tolerance Test

Heterozygote

Source

Open in PubMed

Identifiers

PMID: 9589236
DOI: 10.2337/diacare.21.5.753

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.