Article
Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population.
Genes and immunity - 1 Apr 2002
Ahmed S, Ihara K, Bassuny W M, Kuromaru R, Kohno H, Miyako K, Matsuura N, Iwata I, Nagafuchi S, Hara T
Abstract excerpt
CD30-CD30 ligand (CD30L) signal transduction appears to protect against autoimmune diabetes by preventing expansion of autoreactive T cells and suppressing Th1-cytokine response. The purpose of this study was to determine whether CD30 or CD30L genes serve as a novel susceptibility gene for type 1 diabetes in humans. We screened CD30 and CD30L genes for polymorphisms in Japanese patients with type 1 diabetes and...
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