Article
TIM-3 polymorphisms in type 1 diabetes families.
Journal of human genetics - 1 Jan 2008
Brück Patrick, Ramos-Lopez Elizabeth, Bartsch Wiebke, Böhme Angelika, Badenhoop Klaus
Abstract excerpt
TIM-3 is a transmembrane protein preferentially expressed on differentiated Th1 cells, which play a role in Th1-mediated diseases including type 1 diabetes. We investigated the role of the rs10515746 (A/C), rs1036199 (A/C), and rs10053538 (A/C) single nucleotide polymorphisms (SNPs) within the TIM-3 gene in 186 German type 1 diabetes families (558 individuals) and its interaction with human leukocyte antigen...
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