Article

Two novel mutations in Gli-similar 3 in patients with congenital hypothyroidism and thyroid dysgenesis

2021-04-28

Abstract excerpt

<h4>Background: </h4> Thyroid dysgenesis (TD) is the main cause of congenital hypothyroidism (CH). As variants of the transcription factor Gli-similar 3 ( GLIS3 ) have been associated with CH and GLIS3 is one of candidate genes of TD, we screened and characterized GLIS3 mutations in Chinese patients with CH and TD. <h4>Methods: </h4>: To detect mutations, we sequenced all GLIS3 exons in the peripheral blood genomi...

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Literature Corpus work: 1d040c67-50aa-58be-bf1c-f001533170fd
DOI: 10.21203/rs.3.rs-425460/v1

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